Canadian researchers say they have developed the first drug effective against acne. Meanwhile, the laser or HAART could revolutionize the treatment of skin disease that affects 85% of adolescents. Back on the latest discoveries.
Until now, the cons acne solutions are not always effective. The treatment of disease but also the scars that result are a major headache. New therapeutic approaches may soon offer effective weapons against this skin disease.
A very promising new compound
Acne treatments demainLors's largest global conference on antimicrobial agents, the company Micrologix Biotech Vancouver has announced a discovery that could date. Results 1 of its molecule MBI 594AN leave because bode sad tomorrows for acne.
While clinical trials of phase II with 75 patients is underway, further in vitro studies demonstrate the effectiveness of the new compound against the bacteria responsible for acne (Propionibacterium acnes) even against strains resistant to current treatments . In total, 27 samples of resistant bacteria were tested and all proved sensitive to MBI 594N.
This clarification is particularly interesting that the emergence of resistance vis-à-vis the common treatments is becoming more worrisome. At the heart of this "wear" the development of protection from the bacteria that would have almost tripled in 30 years. But the new compound would destroy the bacteria by puncturing the membrane without the latter has time to develop any defense mechanism. Thus, attempts to initiate resistance patterns have all proved failures.
However, it will take more studies and further clinical trials to determine whether this new compound is indeed a bright future.
The laser and cons peel acne scars
During the summer conference of the American Academy of Dermatology, Dr. Goldman said that the laser now offers new possibilities in the treatment of acne scarring. His study2 on 14 patients highlighted the effectiveness of the YAG laser which, without anesthesia, allowed a significant improvement in skin appearance.
But this treatment is not the only recourse. Thus different techniques coexist all the responsibility of the specialist: cryotherapy, exfoliation, peels, dermabrasion with rotating wheels, etc..
Dermabrasion is to erode the epidermis and dermis layer with a hard or abrasive cylinder under local or general anesthesia. Healing is usually achieved after one week. Be careful though to avoid sun exposure for two months.
In all cases, the treatment of acne scars is possible only when the disease is more scalable.
Towards HAART against acne?
"Now, acne can be treated by the combination of different therapies, such as the use of chemical peels or laser, which have amazing results" said Dr. Vidimos. The dermatologist said that the combination of techniques offers new therapeutic possibilities.
Although the use of oral antibiotics does not improve the appearance of acne scars, dermatologists have other options. "The acne scars are unique in appearance and often have complex characteristics that must be taken into account, such as depth, shape and location," says Dr. Vidimos. Thus, the use of lasers such as pulsed carbon dioxide (CO2) and YAG laser are tools to not overlook.
Acne: treatment of Tomorrow
Pill and Acne: make the right choice!
The pill may improve or even erase acne ... but some of the worse! How to choose the most appropriate? With Doctissimo, make the right choice.
Pill and acne basically a meeting of hormones than the pill, most often a combination of an estrogen, the éthynilestradiol more or less determined, and a progestin for 1st, 2nd, 3rd and now 4th generation. In addition to sex hormones particularly "effervescent" in adolescence. From this shock depends on hormonal changes include an acne.
Each profile hormonal
A girl who has rules very heavy, painful breasts that swell late in the cycle course profile "estrogenic". It feels more comfortable with a pill to "climate progestin.
Conversely, a girl who has lots of acne and / or a tendency to hirsutism (excess hair growth) has rather a "profile" progestogen ": the production of sebum (grease) in the skin is effect dependent on a number of hormones, especially testosterone and progesterone. This acne should be improved with a pill climate "estrogenic".
A suitable climate pill
All pills, by definition, block the functioning of the ovary that secrete more hormones, androgens lead. Furthermore, if estrogen, the same for all pills has beneficial effects on this "problem" skin is the type of progestin partner who makes the difference between the pills on acne in particular. ..
* Thus, the pills "old" from 1st to 2nd generation have a progestin derivative of testosterone, said androgen (levonorgestrel or norethindrone), similar to the effects of male hormones, which may consequently aggravate acne. This progestin outweighed the combined estrogen and the pill, then climate progestin promotes acne in women who are prone, as well as hair growth ... It is preferred when it comes to reducing the volume of rules, relieving the tension of the breasts or heavy legs. A delicate balance.
* By cons, when progestin is the 3rd generation (gestodene, desogestrel and norgestimate), "non-androgen, estrogen is the right thing and the climate of this pill are estrogenic. What is desired in case of acne. We can neutralize androgens by an estrogen pill estrogen climate certainly, but also choosing an anti-androgenic progestin (not just "non-androgen") such as cyproterone (Diane), chlormadinone acetate (Belara) or drospirenone (Jasmine Jasminelle). The latter have more of an effect antialdostérone opposing fluid retention caused by estrogen, and can avoid some swelling or weight gain from water retention.
Attention Diane is not considered a contraceptive, as stated on his notice: this molecule, which is not without side effects, has not been tested for this indication and is primarily a treatment hormonal women with hyperandrogenism, resulting in acne and hirsutism especially.
None of the 3rd generation pills (to climate estrogen), progestin that is non-or anti-androgen, a priori all effective on acne, is reimbursed in France (only the 2nd generation pills, progestin-climate, the are).
Dr. Brigitte Blond
Acne: what are the causes of Acne
Blackheads, whiteheads ... As a teenager, acne often prevents seeing la vie en rose. But what are the causes of this skin condition that affects nearly 80% of young people at the first stirrings of love? Passing in review the three main culprits.
Acne is a disease affecting the hair follicle at the root of our hair. At its core are the sebaceous glands responsible for production of sebum, preventing the fat dries out the skin. But during puberty, this well-oiled mechanism jammed!
Acne in three steps
The emergence of a button at the follicle is due to the conjunction of three events:
• excessive secretion of sebum in the follicle;
• Obstruction of the follicle (for reasons as yet unknown);
• Development bacteria inside the follicle.
During puberty, the production of male sex hormones (androgens) leads to an excess of sebum in sebaceous glands. The excess sebum flows to the surface of the skin becomes oilier. But the channel is encumbered and the pore is blocked, is the appearance of black spot or comedo or microcysts white.
Cutting the skin
Subsequently, the development of inflammation within the follicles and infection of them by a bacterium, Propionibacterium acnes, causes buttons (papules, pustules and nodules).
Stress and heredity
Stress is accused of all evils, and it is sometimes accused of being responsible for the appearance of acne. We also know that stress can affect hormone levels. It could therefore influence the development of this skin disease. But according to the latest review to date, its role remains to this day the subject of controversy and it is singularly lacking in validated scientific studies on the subject.
Moreover, many studies2 note a significant number of patients of both sexes in the same family. Although genetic susceptibility has been suspected, no scientific evidence has been made to date.